Some people may have, for example, a 'holiday romance,' which is essentially what Drully are having, only it is on national tv and being zoomed around the internet. People say 'I couldn't live with myself...' but you don't die of having an affair. You must live with yourself, cause maybe the loved one is gone when they find out, or maybe you never say a word, Brief Encounter style. Either way, you are still there, being you, not being dead, living with yourself.
Some psychologist, or maybe it was a philosophical Polish bikie down the pub, pointed out that once you do something - a crime, a sin, whatever you call it, once you breach your internal sense of right and wrong - which is different for everyone unless you have signed on to a dogma dictating exactly what to think on every issue, which is valid - once you breach these rules of what you yourself think is wrong, in order to live with yourself, to reduce the cognitive dissonance your internal morals change, and can grow to encompass the new behaviour. It is why we always find the second murder easier.
Some of this should be going on in Tully and Drew, unless they are both sociopaths or something. Or, maybe not. Maybe Drew thinks it is not cheating if you are single - it is her problem, not mine. Some people do see it that way. Dunno with Tully. She seems unable to acknowledge that she has vreached a boundary. Maybe she feels she hasn't, but I suspect some pretty hefty denial going on, which seems habitual of her behaviour in this incredibly intense and specifec experience of being in that house.