Considering they only use two way mirrors these days during key events I could see the house design changing slightly. They’d no longer need the huge central void and can just run corridor around the outside. I also think they’d probably rearrange the bedrooms so that they don’t have a grouping of three and then the HN room on the upper level.Yes, a new team would do the show a world of good.
As for the house - considering when they moved back in 2005 they basically did little more than flip the layout and add the HoH room above I wouldn't be surprised if they did little more than just rebuild it. Indeed that is pretty much all Canada did when they moved second time around - indeed first time around all they did was lift the bedrooms to the second floor really. However they have a much better core layout with a design team which genuniely makes the house feel different from year to year despite the layout being essentially the same.
Like I said before I think the key element of a new location should be a separate competition space.